Systemic Lupus Erythematosus Autoimmune Disorder

Systemic Lupus Erythematosus Autoimmune Disorder AUTOIMMUNE DISORDERS The immune system is an important system within the human body that defends against disease and internal malfunction. When there is an invader or a pathogen, the bodys immune system responds accordingly, usually destroying the pathogen before it can infect the body and cause illness. The immune system also helps identify malfunctioning cells and eliminates them before faulty DNA is replicated. Autoimmune disorders occur when the immune system of a patient no longer identifies foreign versus self correctly. The immune system of a patient with an autoimmune disorder will attack the bodys cells or tissues causing damage or death. (Lettre Rioux, 2008). Autoimmune disorders can be genetically predisposed, but just because a patient is predisposed to a particular disorder does not mean they will necessarily experience it. Often times, autoimmune disorders occur through a combination of genetic predispositions and environmental factors. This means a patient may have a genetic predisposition for systemic lupus erythematosus but the disorder is triggered by an invading virus the patient encounters and only thereafter do they suffer from the symptoms of SLE. There are now 68 genetic precursors that are linked to the development of autoimmune disorders, while in the past only about 15 had been identified. Symptoms of autoimmune diseases vary depending on what part of the body the immune system is attacking (Understanding Autoimmune Diseases, 2016) (Lettre Rioux, 2008). Within the immune system there are several types of cells. B-cells and T-cells play key roles within the immune system and in autoimmune diseases. There are two types of T-cells, CD4 T-helper cells that identify an invader and make the antibody creating B-cells aware and CD8 cytotoxic T-cells which will destroy a previously encountered threat without stimulating the creation of antibodies by B-cells. CD4 T-cells are also known as regulatory T-cells (Treg cells). These Tregs play a role in preventing autoimmunity by maintaining the ability to identify self. When these cells no longer identify self properly or at all, an autoimmune disease occurs. When T-helper cells do not identify self-versus-foreign properly they stimulate B-cells to create antibodies to destroy the bodys tissues or cells, called autoantibodies, or the cytotoxic T-cells will destroy the tissue or cells of oneself. (Venes et al., 2005, pp. 132, 135, 203, 204) (Corthay, 2009) (Hampe, 2012). SLE or Systemic Lupus Erythematosus is an autoimmune disease most commonly characterized by joint pain (arthralgia) and swelling (edema). SLE can also cause fatigue, mouth sores, sensitivity to sunlight, and butterfly rash across the cheeks and nose of the face, and hair loss. Other symptoms depend on where the body is being attacked by the immune system. For instance, if the immune system of a patient with SLE is attacking the heart of the patient an additional symptom of arrhythmia may be experienced. (Systemic Lupus Erythematosus, 2016). Diagnosis of SLE can be difficult as it can be associated with varying symptoms. A test known as antinuclear antibody test (ANA) is used to help diagnose SLE. An antinuclear antibody is an antibody created by the patients immune system to attack the bodys tissues and cells. Some ANA tests are enzyme-linked immunosorbent assay (ELISA) and indirect florescent antibody (IFA). These tests examine how many antinuclear antibodies are present in a patients blood. ANA tests are used when the autoimmune disease may be affecting more than one area of the body; this is called a systemic autoimmune disease. Because SLE is systemic, an ANA test helps confirm that SLE is the diagnosis as opposed to rheumatoid arthritis. However, having a positive ANA test does not mean that a patient has SLE. SLE is often misdiagnosed as rheumatoid arthritis because they share common symptoms such as edema and arthralgia this is why doctors often use an assortment of other tests to diagnose SLE, along with a physi cal exam as four of the eleven common symptoms of SLE must be present before a patient can be diagnosed. Some of those common symptoms were listed above: butterfly rash across the face, joint pain, sensitivity to sunlight, hair loss, fatigue, and edema. (Antinuclear Antibody, 2017)(Starkebaum, 2016)(Bocco, 2017). Systemic Lupus Erythematosus can be treated but not cured. Because it is an autoimmune disease, SLE is treated with immunosuppressants. Hydroxychloroquine (HCQ) is an immunosuppressant that slows down the immune system and its attack on the bodys tissues and cells. HCQ was originally used in the treatment of malaria and is known as a disease-modifying anti-rheumatic drug (DMARD). It is recommended that patients diagnosed with SLE immediately start a HCQ regiment as this drug help prevent further damage from the disease process. HCQ is usually used in chorus with other pain relief drugs because HCQ itself does not provide immediate pain relief. NSAIDS (nonsteroidal anti-inflammatory drugs) are often used in joint pain management for patients with SLE. Over time, HCQ will help relieve joint pain in SLE sufferers as well as help stop further damage to any other affected organs and joints. Corticosteroids are often also prescribed to those with SLE as joint pain is a prominent symptom of SLE. Corticosteroids mimic naturally produced strong anti-inflammatory substances within the body. However, treatments come with risk factors. In rare cases, HQC can cause retinopathy; retinopathy is when vision is altered or complete blindness occurs. Likewise, long term use of corticosteroids has adverse effects including: osteoporosis, hyperglycemia (high blood sugar), and cataracts. Dosage of corticosteroids are adjusted for long term use in patients with SLE to avoid these side effects and routine eye exams are done on those using HCQ to prevent retinopathy. (Plaquenil (hydroxychloroquine), 2014) (Bartels, 2016) (Mayo Clinic Staff, 2015). Systemic Lupus Erythematosus predominantly affects women. Research suggests this is due in part to estrogen. For every one man diagnosed with SLE, there are nine to twenty women diagnosed. Within the population of women who are at risk for SLE, women who are not white are at a higher risk for SLE as well as women under the age of 15 and over the age of 45. The discrepancy in race may have to do with the fact that colored females have higher recorded levels of estrogen than do white females.   Estrogen is thought to make women more susceptible to an autoimmune disease such as SLE because of its intracellular transcription ability to alter DNA. The effects of estrogen have also been studied holistically in association with the disease. Estrogen may encourage systemic inflammation in SLE and affect the severity of the disease and acute instances of it. Although estrogen has been identified as causing inflammation it has also been identified as prohibiting inflammation; thus meaning es trogen can act oppositely as it does in SLE in terms of another autoimmune disease. The discrepancy between the genders cannot completely be accounted for primarily with estrogen levels, however. Sex hormones are not the only determining factor for autoimmune diseases, others include; epigenetics, infections, genetics, and external environment. (Pierdominici Ortona, 2013, pp. 25-27) (Khan Ahmed, 2015) (Isherwood Witter, 2012) References Antinuclear Antibody (ANA). (2017, March 22). Retrieved March 23, 2017, from Lab Tests Online website: https://labtestsonline.org/understanding/analytes/ana/tab/test/ Bartels, C. M. (2016, September 19). Systemic Lupus Erythematosus (SLE) Treatment and Management (H. S. Diamond, Ed.). Retrieved March 23, 2017, from Medscape website: http://emedicine.medscape.com/article/332244-treatment Bocco, D. (2017, January 3). The Difference Between Lupus and RA (N. Carteron, Ed.). Retrieved March 23, 2017, from Healthline website: http://www.healthline.com/health/lupus-and-ra#Overview1 Corthay, A. (2009, June 27). How do Regulatory T Cells Work? Retrieved March 22, 2017, from NCBI website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784904/ Hampe, C. S. (2012, September 23). B Cells in Autoimmune Diseases. Retrieved March 22, 2017, from Hindawi website: https://www.hindawi.com/journals/scientifica/2012/215308/ Hansen, M. S., Schuman, S. G. (2011, June). Hydroxychloroquine-Induced Retinal Toxicity. Retrieved March 23, 2017, from American Academy of Ophthamology website: https://www.aao.org/eyenet/article/hydroxychloroquine-induced-retinal-toxicity Isherwood, D., Witter, J. (2012, July 16). Lupus fact sheet (B. Diamond, Ed.). Retrieved March 24, 2017, from Womenshealth.gov website: https://www.womenshealth.gov/publications/our-publications/fact-sheet/lupus.html Khan, D., Ahmed, S. A. (2015, December 3). The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases. Retrieved March 24, 2017, from NCBI website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701921/ Mayo Clinic Staff. (2015, November 26). Prednisone and other corticosteroids. Retrieved March 23, 2017, from Mayo Clinic website: http://www.mayoclinic.org/steroids/art-20045692?pg=2 Pierdominici, M., Ortona, E. (2013). Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus. International Trends in Immunity, 1(2), 24-34. Retrieved from http://researchpub.org/journal/iti/number/vol1-no2/vol1-no2-3.pdf Plaquenil (hydroxychloroquine). (2014, February 10). Retrieved March 23, 2017, from Netdoctor website: http://www.netdoctor.co.uk/medicines/aches-and-pains/a7356/plaquenil-hydroxychloroquine/ Starkebaum, G. A. (2016, January 16). Systemic lupus erythematosus. Retrieved March 23, 2017, from MedlinePlus website: https://medlineplus.gov/ency/article/000435.htm Understanding Autoimmune Diseases. (2016, March). Retrieved March 22, 2017, from National Institute of Arthritis and Musculoskeletal and Skin Diseases website: https://www.niams.nih.gov/%5C/Health_Info/Autoimmune/default.asp Venes, D., Biderman, A., Adler, E., Fenton, B. G., Enright, A. D., Patwell, J., . . . Wight, A.-A. (Eds.). (2005). Tabers Cyclopedic Medical Dictionary (20th ed.). Philadelphia, PA: F.A. Davis Company.

Essay --

Plato: Republic: By Allan Bloom In the Plato’s Republic mainly discuses the idea of what justice is. The answer to this question has a variety of answers according to the Republic, which makes it very interesting. Throughout this book, you will be driven in many directions of what justice is. Some may the answer is to primarily is doing the right thing. The main issue comes from about is whether to try and be just at the expense of staying poor, or lie, or even use the very unjust means to get what one wants in life. The main point of the book is a man who tries to be very just, may spend life wandering in the streets in search for money, while the man who lies to get their way, will be rich. This essay looks at the Thrasymachus’s concept of and the Socrates’s concept of justice. The essay also looks at the author thinks that the unjust man will be happier that the just man. It explores the reasons why the concepts are right or wrong. In book one, Thrasymachus definition of justice is, â€Å"the advantage of the stronger† (341d). His view on justice that justice always gives more authority and rule to people who are already in power. The argument that Thrasymachus makes is difficult to understand. His statement may make one believe that the people who are being ruled are considered to act right when their actions are going towards benefiting the rulers. You can also make an interpretation that the ruling class acts fairly by doing things that will benefit them. The confusion comes because Thrasymachus expresses his belief that, when the ruling classes do things that is geared towards benefiting them, they are acting unfairly. In his quote he says â€Å"advantage to the stronger†, which means Thrasymachus is arguing the concerns of justice... ...ons of the people. Socrates brings out the argument that the leaders do whatever they do for the interests of the people. The leaders are stronger than the citizens, the leaders should consider the people as their bosses and work for them. This explains why Socrates accepts that everything the leaders say or do. They do things with the interests of the others. As Socrates argues, leaders are not in power to benefit them. They are in power to serve the interests of the people who put them to those positions. In conclusion, the concept of justice defined by Thrasymachus and Socrates has opposing views. Thrasymachus views justice as making one unhappy. He says that lying and stealing is a way out. On the contrary, Socrates brings out justice as a pure of the soul. Socrates reflects the wishes of the society while Thrasymachus reflects a society that has rotten values.

Destruction in Erich Maria Remarques All Quiet on the Western Front :: All Quiet on the Western Front Essays

Theme of Destruction in Erich Maria Remarque's All Quiet on the Western Front Everyone knows what war is. It's a nation taking all of its men, resources, weapons and most of its money and bearing all malignantly towards another nation. War is about death, destruction, disease, loss, pain, suffering and hate. I often think to myself why grown and intelligent individuals cannot resolve matters any better than to take up arms and crawl around, wrestle and fight like animals. In All Quiet on the Western Front, Erich Maria Remarque puts all of these aspects of war into a vivid story which tells the horrors of World War 1 through a soldier's eyes. The idea that he conveys most throughout this book is the idea of destruction, the destruction of bodies, minds and innocence. The author starts off his book with a note highlighting the meaning of this book. It is as follows: This book is to be neither an accusation nor a confession, and least of all an adventure, for death is not an adventure to those who stand face to face with it. It will try simply to tell of a generation of men who, even though they may have escaped shells, were destroyed by the war.(Intro) Right after reading this paragraph, I knew that none of this book was to be comical or heroic. It was not going to be one of those stupid stories romanticizing war and making heroes out of men who killed more of the enemy than anyone else; this book was about destruction. These few lines before chapter one set the whole tone for the rest of the book. Glory does not exist in this story, only death and sadness. The story takes place through the eyes of a German infantryman named Paul Baumer. He is nineteen and just joined up with the German army after high school with the persuasion of one of his schoolteachers, Mr. Kantorek. Paul recalls how he would use all class period lecturing the students, peering through his spectacles and saying: "Won't you join up comrades?"(10). Here was a man who loved war. He loved the "glory" of war. He loved it so much as to persuade every boy in his class to join up with the army. He must have thought how proud they would be marching out onto that field in their military attire.

Climate Change Caused by Human

Examine the role of one human activity in causing climate change With the rapid development of contemporary society, the balance between human and the nature has been destroyed. The increase of globally averaged temperature on the earth’s surface has occurred over the past century. Thus, climate problems have been the initial international issue to be handled. Industrial production is one of human activities causing climate change. Firstly, this essay will analyze how carbon dioxide and small carbon particles lead to climate change.Secondly, this essay will present the cooling effect of Feron on global temperature. Finally, this essay will discuss how deforestation in expanding industrial land changes climate. The combustion of fossil fuels is inevitable in industrial production, because it provides extreme high temperature and continuous heat. It is the direct contributor to climate changes by emitting large amounts of greenhouse gases, such as carbon dioxide, methane, sulfur dioxide and nitrogen dioxide. The concentration of carbon dioxide has increased since industrial revolution.In the past ten years, the situation has deteriorated, as the increase in the concentration has become far quicker than previous predictions (Adam, 2007). The majority of carbon dioxide emission results from fossil fuels. Due to the increasing atmospheric concentration of carbon dioxide, more sun energy is absorbed and trapped in the atmosphere, enhancing greenhouse effect (NDPI, 2008). Not only greenhouse gases but also carbon particles, consisting of heavy smoke which is produced by burning fossil fuels, are responsible for climate change.These particles gather in clouds, increasing the density of the atmosphere, which causes sun heat radiation be absorbed and trapped inside the earth without being released. With less heat reflecting back to the space, negative impacts on earth’s warming are amplifyed. Consequently, burning fossil fuels in industrial production is a major cause of climate change. Freon, used as refrigerant in some industrial equipment, is another greenhouse gas that contributes to climate change.This gas will corrode ozone layer, which helps to prevent ultraviolet rays from reaching the Earth, by several chemical actions; whereas the gas itself plays the role of catalyst, which means it will not reduce when decomposing ozone. If the earth is exposed to excessive ultraviolet rays, humans will suffer from skin diseases and the ecological environment will be under a dangerous condition. The news said that both Antarctic and Arctic sky had holes and the holes were expanding. It is a warning that requires effective measurements to reduce the release of Freon.Contrary to general perspective, the depletion of ozone has a net effect on cooling the Earth’s surface instead of warming it (Hamgurg, 1997). However, this greenhouse gas is still responsible for climate change. In order to enlarge factories, people require more flat lan d, leading to deforestation, which is another cause of climate change in industrial production. Thousands of forests are being cut down every year, posing a serious problem that destroying the balance between carbon and oxygen to the nature.If the area of forests continue to reduce, extra carbon dioxide cannot be absorbed and not enough oxygen can be produced, which means that the nature will lose the capability of adjusting the composition of atmosphere. Without the proper percent of oxygen in the atmosphere, various plants will be unable to survive, resulting in the increasingly severe destruction of the carbon and oxygen balance. Eventually, this negative cycle in the nature enhances climate change. In conclusion, industrial development plays a vital role in climate change.The emission of Feron erodes ozone layers, which cools the temperature; the combustion of fossil fuels in order to gain extreme high temperature and provide continuous heat, as well as deforestation which creat es more space for factories, increase the concentration of carbon dioxide in the atmosphere, which is a significant cause of the warmer climate. Reference: Adam, D. (2007) Carbon output rising faster than forest, say study. The Guardian online. Available at: http://www. guardian. co. k/environment/2007/oct/23/climatechange. canbonemission (Access 17 January 2011) Hamburg, S. R. et al. (1997) What Human Activities Contribute to Climat Change? Washington DC: United Environment Programme-World Meteorological Organization. Available from: http://www. gcrio. org/ipcc/qa/06. html (Accessed 17 January 2011 ) NSW Department of Primary Industries (2008), What is climate change? Available from:http://www. dpi. nsw. gov. au/research/topics/climate-change/cause (Accessed 17 January 2011)

Competition in the Golf Industry

An Analysis of â€Å"Competition in the Golf Industry† It is unknown when the game of golf originated, but it is believed that people began playing in Europe during the middle ages. In the United States, golf was a sport primarily played by the wealthy individuals until tournaments began being televised. Since then, golf has grown to be a very lucrative industry with over 27 million golfers nationwide by the end of the 1990’s. â€Å"Competition in the Golf Equipment Industry,† a case study written by John E. Gamble of the University of South Alabama, is an overview of the problems currently facing major companies in the golf equipment industry: technological limitations (due to golf’s governing organizations), a decline in the number of golfers, and the economic recession, and the threat of counterfeit products. These limitations are causing leading competitors in the golf industry, namely Calloway Golf, to rethink their strategies in 2010. PLAC Analysis for Calloway Golf Ely Reeves Calloway Jr. , Calloway’s original owner, CEO and President, bought a manufacturing company of hickory shaft wedges and putters in 1983. Calloway, originally restricted to reproducing antique golf clubs, has extended its product breadth across the golf equipment industry. Calloway Golf now encompasses drivers (with the introduction of Big Bertha), putters (with the acquisition of Odyssey), irons (designed to compete against Titleist), golf balls (with the acquisition of Top-Flite), footwear and clothes branding, and GPS units (with the acquisition of UPlay). See Timeline in Appendix 1. Calloway has differentiated itself from its competitors by its innovation, beginning with the success of their driver, Big Bertha, which initiated the technology race among firms. Calloway and its’ competitors introduce more innovative products every 12-18 months to remain competitive. Furthermore, Calloway has acquired several firms since its origination in 1983 in order to expand its product breadth. Although in 2009, Calloway Golf Company was the â€Å"second largest seller of drivers and fairway woods,† revenues have declined by 17% in 2009 compared to the first six months of 2008. Challenges facing this firm will be assessed in the SWOT analysis. SWOT Analysis for the golf industry, Calloway Golf & Recommendations See Appendix 2 for Matrix Strengths: Calloway’s technological innovation in making a driver that pushed the limits of USGA standards shows motivation to become the best. Marketing to recreational golfers in an attempt to help them enjoy the game more by offering an opportunity to drive 6-10 yards further was a benchmark and pushed Calloway’s product to the best golf product of the century by a two-to-one margin. Calloway’s recognizable name also gives them a competitive edge. Weaknesses: Although these technological advances may have boosted sales, there is still little evidence that these advances help golfers lower their scores. Another weakness of the industry is sustainability. With the development of new products every 12-18 months, it is crucial that companies market their products and have strong sales shortly after introduction. Also, a weakness with Calloway’s golf balls was their brand image with the acquisition of Top-Flite golf balls, which quickly coined the game â€Å"Rock-Flight. † Opportunities: Although sales have declined 5. 7% during 2008, continued marketing efforts and remaining a household name could prove beneficial to all firms after the recession has subsided. Due to the recession, discretionary spending has declined and savings has risen, but this could quickly change after a turn in the economy. Furthermore, Calloway has recently cut their endorsements of PGA professionals to only encompass 10 men’s PGA professionals and 5 women. If they expanded these numbers, it would give them more brand exposure and possibly higher revenues since many recreational golfers base their decisions on the type of equipment successful, professional golfers are using. Threats: There are a number of threats affecting the golf industry as a whole: effects of technological limitations by USGA, a decline in the number of golfers due to the economy and lack of leisure time, and the rise of counterfeiting. The state of the current economy paired with the decline in the number of golfers, has caused companies to focus more on price and volume. Counterfeiting is largely attributable to the decisions by executives to outsource for cheaper labor to manufacturers in China; who can produce a golf club for less than $3 per club. Recommendations Companies currently operating within the golf industry, specifically Calloway Golf, must change their current marketing approaches and strategies to withstand the recession and threats facing the industry. Although Calloway has a strong R&D department that tends to remain competitive with products and technology, there have been little results in reference to scores. It is imperative that if companies are going to market a product that will help golfers drive further and straighter that the results depict this so that not to damage the brand name of a product. Secondly, due to the decline in equipment sales and the number of golfers, prices are dropping and companies are outsourcing to maintain the volume needed to remain competitive. Companies must be cautious and aware so that counterfeiting may be reduced. This reduction would also allow companies to reduce their pricing and have more sales without the competition of these cheaply priced knock-offs. In the instance of Calloway, an increase in marketing and endorsements would boost their sales due to brand recognition. Calloway has recently fallen to second place in the amount of sales of drivers. In aiding in cutting down on counterfeiting, lowering prices, and increasing marketing and endorsements, Calloway may have the opportunity to reposition themselves as number one in the marketplace. Appendix 1 Calloway Timeline 1983- Ely Reeves Calloway, Jr. purchased a 50% interest in a Temecula, California manufacturer and marketer of hickory shafted wedges and putters for $400,000. 1985-Ely Reeves Calloway, Jr. , hired aerospace and metallurgical engineers to design the most technologically advanced golf clubs. 1991- Introduction of Big Bertha 1996- Acquisition of Odyssey (leading brand of putters)

Daily Time Record

This Automated Student Attendance Daily Time Record focuses on the need to design a system that will automatically arrange the record and calculate the average attendance of each student. A well-conceived and implemented automated student record system can reduce the costs of handling the paperwork associated with record keeping. Manual attendance record system is not efficient and requires time to arrange record and to calculate the average attendance of each individual student. Automated Student Attendance Daily Time Record is intended to replace the manual model of attendance record keeping. Our school using ball pen or log book to record a attendance this system need a computer and the student will record his attendance with a password and the system will arrange the record and calculate the average attendance of the student. The system contains attendance record in electronic files containing details of absence or presence of a specific student enrolment during a semester. Attendance records have been collected on paper forms and verified with hand written signatures. However, the increasing demand for automated student attendance daily time record should be implemented as soon as possible in order to reduce the costs of handling the paper works with record keeping. This system described in this document should be implemented also in different school and all automated systems must follow the standard procedures. This project will try to organize the current school attendance record system that will be much quicker and will save time. Statement of the Problem The study was conducted to some school that does not have automated student information daily time record. Specific Problem. Does our some school have this system? †¢What is the importance of having this kind of system? †¢Is there any summary report for the attendance weekly or after the semester? †¢Is the system reliable to keep all the attendance records? Objective Design and create a system that could calculate and get the average attendance of the student more efficient, reliable and less time in a semester. Specific objective †¢Create a system the will calculate the average of attendance of each of individual student †¢Arrange the record accordingly. †¢Reduce the costs of handling the paperwork associated with record keeping.

Environmental Issues Can Be Handled Without Compromising on Profits Research Paper

Environmental Issues Can Be Handled Without Compromising on Profits - Research Paper Example The strategic avoidance or minimal compliance with the regulations pertaining to environmental management has led the corporations to environmental pollution or degradation of the environment. The managers are usually faced with difficult situations when they have to trade-off between economic profitability and concern for the environment. However, firms can address the environmental concerns while remaining sustainable although different firms may follow a different path to achieve the objectives. Managers’ commitment to sustainable development can be a source of competitive advantage but they view strategic environmental issues as threats (Là ³pez-Gamero, Claver-Cortà ©s & Molina-Azorà ­n, 2007). It has also been found that the number of resources available to the organization as well as the size of the firm determines the firm’s orientation towards appropriate environmental initiatives. This is evident from the case of the Body Shop and its take over by L’Oreal. Body Shop is known for its ethical stand on animal testing, human rights, community trade and the environment (Glasgow, 2006). The Body Shop had been positioned as an ethical and green-conscious business, believing in fair-trade practices (Alarcon, 2008). Body Shop had been seeking financial support and when the takeover was decided, it was also agreed that Body Shop would continue to operate as an independent unit. L’Oreal is 25% owned by Nestle and is a brand in itself. While Body Sh op was dead against testing its cosmetics on animals, L’Oreal has always been doing this. L’Oreal’ has refused to sign the Compact for Safe Cosmetics – a Code of practice – that requires the removal of potential carcinogens and other toxins from beauty products (Russell, 2007).